Molecular Devices Upgrades CellXpress.ai for Automated Brain Organoid Culture
Molecular Devices, LLC has introduced a significant upgrade to its CellXpress.ai Automated Cell Culture System by integrating rocking incubation technology. This enhancement supports the development and long-term maintenance of brain organoids, reducing manual labor and speeding up research on neurodegenerative diseases.
Addressing Challenges in Brain Organoid Cultivation
Brain organoids are 3D mini-models of the human brain used to study neurological disorders. Cultivating these models is labor-intensive, often requiring daily feeding and monitoring for over 100 days due to their high metabolic needs and sensitivity to nutrient distribution. The new rocking incubator automates nutrient flow, maintaining consistent conditions.
By combining this with AI-driven decision-making, the system ensures steady, healthy organoid growth over extended periods without constant human intervention. This reduces the risk of variability and supports reproducible results essential for reliable research.
Time Savings and Workflow Flexibility
Maintaining just 10 brain organoid plates manually demands nearly 27 hours of hands-on work weekly. Automation cuts this down to a few hours, freeing researchers to focus on data analysis and experimental design.
The rocking incubation is integrated into a modular rack design that offers both rocking and static conditions. This supports simultaneous stem cell maintenance and organoid growth, enabling a seamless workflow from cell culture to downstream assays.
Precision, Consistency, and Data Tracking
- Automated feeding and imaging on fixed schedules, including weekends, reduce variability in treatment across samples.
- Maintains optimal media conditions at 37°C, minimizing risks of cross-contamination.
- Captures full-well images equipped with advanced feature analysis, allowing researchers to monitor cell development over time.
These improvements provide scientists with more consistent data and preserve culture integrity, which is critical for studies involving complex 3D biology.
Advancing 3D Biology and Drug Discovery
The upgraded CellXpress.ai system simplifies complex workflows, improves reproducibility, and accelerates drug discovery by making human-relevant models more accessible. This reflects Molecular Devices’ ongoing commitment to helping labs scale complex biology research efficiently.
For researchers interested in automating lab workflows and incorporating AI-driven tools, exploring relevant automation courses may provide additional practical skills to maximize the benefits of such systems.
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