Synthesis Route Planning Agent

Planning a synthesis means choosing steps, reagents and conditions that work together, and a route that looks good on paper can fail on a missing reagent. When a new target is requested, this agent runs a retrosynthesis search and finds literature precedents for each step. It checks reagent availability and price with the chemist's suppliers, flags hazardous or restricted reagents, and catches steps that clash with protecting groups. It then checks whether at least one route passes every check. If none does, it relaxes only the constraints the chemist allows and searches again. It ranks routes by number of steps, cost and strength of precedent, preferring in-stock reagents, and writes a summary. The chemist chooses the route. Edge case: a step backed by only one weak literature example is labeled risky.